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Types of peptide libraries
Alanine Scanning Library We sequentially substituted Ala for amino acids in the sequence; By scanning peptide libraries with Ala, the effects of specific amino acids on biological activities such as structure and function of the whole protein can be identified. Positional Scanning Library Single ...Read more -
A basic introduction to veracatide Background and Overview
Fmoc-L-Cys(Npys)-OH, Boc-L-Cys(Npys)-OH, H-L-Cys(Npys)-OH and other special protective amino acids were used. Due to their high cost, there are too many disadvantages to form disulfide bonds on the solid phase resin and it is difficult to control. Using low-priced H-L-Cys-OH as the synthetic raw ...Read more -
Structural characteristics of eight polypeptide drugs
Peptide drugs are compounds composed of multiple amino acids linked by peptide bonds, which have important biological activities and therapeutic effects. The structural characteristics of polypeptide drugs include the following aspects: Constituent amino acids: 1. Amino acids: Peptides are compos...Read more -
Interpretation of the latest research on antimicrobial peptide LL-37
What are antimicrobial peptides? Antimicrobial peptides, also known as antimicrobial peptides, are important components of human natural immunity and widely present in natural organisms. They are small molecular peptides with biological activity induced by organisms. Two main types of antimicrobi...Read more -
Use and mechanism of action of olaparib
Olaparib is a chemotherapeutic agent for patients with recurrent or advanced ovarian and metastatic breast cancer who have specific mutations and a history of previous chemotherapy. “It was originally defined as continuous or monotherapy for adult patients with recurrent epithelial ovarian, fallo...Read more -
Further exploration of PeptideMassSpectrometry
PeptideMassSpectrometry is a powerful and widely used bioanalysis technology that brings scientists a window into the structure and function of living molecules. This technique provides important information on the sequence, structure, and interaction of proteins, peptides, and other biomolecules...Read more -
What are the effects of melittin and how to obtain it?
Melittin is the core component and main bioactive substance of bee venom, accounting for about 40%-50% of the dry weight of bee venom. Melittin is strongly alkaline and soluble in water. It is one of the most powerful anti-inflammatory substances known to people at present, and has the following ...Read more -
Four characteristics of antimicrobial peptides
These antimicrobial peptides were originally derived from the defense systems of insects, mammals, amphibians, etc., and they mainly include four categories: 1. cecropin was originally present in the immune lymph of Cecropiamoth, which is mainly found in other insects, and similar bactericidal pe...Read more -
What is the polypeptide secretion cycle? Let me give you an idea of the polypeptide secretion cycle
What are peptides? What is the polypeptide secretion cycle? Today, let’s take a look at the secretory cycle of peptides. At different ages, the secretion of various active peptides is also very different. According to the secretion, the life of a person can be generally divided into: ① Sufficient...Read more -
FOXO4-DRI，2460055-10-9
FOXO4-DRI is a pharmacological peptide that competitively binds to p53 and drives senescent cells into the apoptotic process, thereby greatly ameliorating the side effects of aging and chemotherapy. Foxo4-dri (FOXO4-derived Peptide Inhibitor) FOXO4 is a cell-permeable peptide antagonist designed ...Read more -
Peptide class
1. Classical solid-phase synthesis of peptides Solid-phase synthesis of peptides is achieved by fixing amino acids on solid-phase support, and the solid-phase support is usually polymer resin, such as polystyrene-ethylene glycol cross-linked resin, polyacrylamide-polyethylene glycol resin and bio...Read more -
A boon for hemodialysis patients with veracatide
Secondary hyperparathyroidism is one of the complications of chronic renal failure. (PTH) is a disease of excessive secretion. Excessive secretion of PTH leads to the accumulation of phosphorus and calcium dissolved from bone in the systemic cardiovascular system, resulting in hyperkalemia, hyper...Read more