Overview and uses of cerulein

Overview

Caerulein, also known as cerulein, is a skin extract of the Australian frog HYlacaerulea consisting of 10 amino acids. It is a decapeptide molecule supplied by trifluoroacetate that acts as a cholecystokinin analogue on pancreatic vesicular cells and can lead to the secretion of a large number of digestive enzymes and pancreatic juice, resulting in acute edematous pancreatitis. Cerutin can be used to study Nf-κb up-regulation proteins such as intercellular adhesion molecule-1 (ICAM-1) inflammation-related factors such as NADPH oxidase and Janus kinase mediated signal transduction. It has been successfully used to establish models of acute pancreatitis in rats, mice, dogs, and Syrian hamsters (AP). Intravenous fluids are best administered by intravenous, dermal, or intraperitoneal injection. It is widely used in clinical experiments of acute edematous pancreatitis, and in vitro experiments are applied to cell models. In addition, it is used for gallbladder function examination.

Overview and uses of cerulein

Detailed information

Appearance: white powder

CAS number: 17650-98-5

Gutuo No. : GT-F055

Sequence: pGlu-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2

Molecular formula: C58H73N13O21S2

Molecular weight: 1352.4

Solubility: Dissolved in 50mM ammonium hydroxide at a concentration of 1.0mg/ml

Application

1. It is widely used in the modeling of acute edematous pancreatitis in clinical trials.

2. Application to cell models in vitro.

3. Used for gallbladder function test.

To develop a model for the study of acute pancreatitis for the study of cerulein (AP) cell biology, pathophysiological characteristics and the manifestations of organic diseases in acute pancreatitis. In addition to investigating the pulmonary changes of AP disease, it can also effectively indicate the visceral endocrine interaction such as the level of metabolin and CCK. It can also be used to assess rehabilitation and recovery of injured tissues after termination of hazardous substances.

5. Use of Caerulein cerulein (cerulein) and LPS to establish pancreatitis models can produce synergistic effects, the former can stimulate pancreatic enzymes to destroy the pancreas, and continuously activate inflammatory cells to release inflammatory factors. Subsequently, LPS disrupts the normal response of inflammatory mediators, thus developing localized pancreatitis as a systemic severe inflammatory phenomenon.

6. Cerulein can be used to prevent gallbladder pain, renal colic, and intermittent claudication pain. It is generally considered to be an endogenous kephalin antagonist.