Thymus new method is composed of 28 amino acid synthetic polypeptide immune regulator. Thymus method is a kind of uct new drugs, often used in tumor patients, can enhance immunity.
Mechanism of action
The exact mechanism of thymalfasin in the treatment of chronic hepatitis B has not been fully studied, but various experiments have shown that thymalfasin has a significant immune response. It is mainly accomplished by improving T cell function, and it runs through states that involve T cell production, division and refinement, and apoptosis. By increasing the absolute number of lymphoid, intrahepatic natural killer, CD3 and CD4 cells, thymalfasin can play an immunomodulatory role. Pleural fasin can promote the maturation and division of DC cells, and thus promote the maturation and division of T cells. Thymalfasin can activate mitogen or antigen, enhance the production of a variety of cytokines such as interferons human interleukin IL2 and IL3, enhance the expression of interleukin-2 receptor, and make CD4T cells differentiate into THLS, which have significant antiviral effects. By increasing the role of P cells, it can promote the production of lymphocytes in vivo, adjust the proportion of P cell subsets and U cell differentiation, as well as the production of antibodies, stimulate the production of other antiviral lymphokines and macrophages, enhance swallowing function, and improve the function of cellular immune system in cancer patients. It can also remove bacteria, bacteria and viruses from the body. Thymus method book for the nervous system and surrounding endothelium, rise to adjust the role of hippocampal neuron synaptic transmission. Thymus method new excitatory synaptic transmission and the nervous system, can be used to prevent cancer patients caused by cancer treatments such as chemotherapy and neurotoxicity. Pleuraxin has gene regulatory effects, can induce kinase cascade genes, increase cytokine genes, immune response regulatory genes. The up-regulation of thymalfasin on IL-like receptor genes suggests that thymalfasin stimulates antigen presenting cells. “Moreover, the effect of thymalfasin on immune cell growth is reflected in the increased expression of stem cell growth factors and hematopoietic protein genes.”
New sequence of thymectomy
Process of preparation
1. Biochemical extraction method Thymosin preparations (a mixture of peptides) are basically obtained from animal tissues, so the activity is very different. Because it already contains animal protein, there is a higher chance of allergic symptoms. The biochemically obtained method of thymus from human embryonic thymus is new, with very low yield but very good efficacy. Considering the limited raw materials, high price, low yield, and complex acquisition process. , large-scale production difficulties, development prospect is not optimistic.
2. Chemical synthesis Commercially available thymusfasin is mainly generated as SPSS, which is generated and purified by appropriate techniques. Based on the resin, Fmoc was used for solid phase formation, and 28 kinds of amino acids were generated according to thymalfasin in turn. N-terminal amino acids were acetylated with acetic anhydride, and TFA was used as an important cracking reagent for cracking to obtain rough products. The crude product was separated by HPLC to obtain the new thymus method product, which was then further purified to obtain the new thymus method raw material.
There are three types of genetically engineered bacteria 
1) Multiple genes are cloned into the host to obtain target genes, and finally expressed in the form of inclusion bodies. It has been reported that thymmethod novel multi-string genes were established by random annealing and PCR techniques and replicated into Escherichia coli. (2) The generated fusion protein gene was recombined into the media, and the media was transformed into the host to construct the genetically engineered bacteria. For example, based on the signal peptide gene in the plasmid, the expression plasmid was constructed, transformed into Pichia pastoris by electroexcitation, and then the fusion protein was induced by methanol, and then the new thymus method was constructed by enzyme digestion and other means.
Post time: Sep-08-2023