About us:
A peptide is a chain of amino acids linked by peptide bonds. Peptides are mainly involved in protein regulation, angiogenesis, cell proliferation, melanogenesis, cell migration, and inflammation. Bioactive peptides have been widely used in the cosmetic industry in recent decades. Peptides require low molecular weight (> 500 Da), in order to reduce the diffusion of the peptide between the epidermal layers, high stability and solubility. Over the years, the scientific community has developed a small and stable synthetic peptide fragment that activates collagen production and reduces facial wrinkles and pigmentation. Trifluoroacetyl tripeptide-2 (sequence: TFA-Val-Try-Val-OH) tripeptide synthesis, designed as a matrix metalloproteinase and elastase inhibitor. In vitro studies on the protection of ECM by trifluoro-acetyl tripeptide 2(TT2), the synthesis of proteoglycan in cell-matrix interactions, and the effect on progerin synthesis in mature human normal fibroblasts have been recently identified as a co-inducer of cellular senescence. The results suggest that trifluoroacetyl tripeptide 2 has a broader range of anti-aging properties. This reduces progerin synthesis, increases proteoglycan production, and shrinks collagen, thereby reducing wrinkles and improving tissue stiffness. In addition, its anti-wrinkling, anti-flow hanging and skin tightening effects were evaluated in two in vitro split face studies. Trifluoroacetyl tripeptide 2 has been shown to have progressive effects on wrinkles, tightness, elasticity, and sagging.
Can trifluoroacetyl tripeptide-2 delay aging?
Studies have shown that cell senescence is closely related to Progerin. With aging, presenilin accumulates more and more in the body, leading to nuclear defects and DNA damage, leading to a range of skin aging. Trifluoroacetyl tripeptide-2 is an active tripeptide of Elafin, a derivative of elastase inhibitor. It reduces Progerin synthesis and improves skin laxity, sagging and wrinkles.
Mechanism
1. Inhibit the synthesis of Progerin to delay cellular senescence.
2. Promote syndecan production and prolong cell life.
3. Inhibit the activity of matrix metalloproteinases MMP1, MMP3 and MMP9, reduce the breakdown of extracellular matrix proteins and maintain their integrity.
4. Inhibit elastase activity, reduce elastin degradation, and make skin tighter and more elastic.
Application
It is suitable for all kinds of anti-wrinkle and anti-aging, firming repair, anti-photoaging, post-natal and post-sun body care, etc. It is added in the final stage of cosmetics production
Post time: May-22-2023